Primary Responsibilities

·Nominate targets for liver-targeting indications, including but not limited to metabolic diseases, cardiovascular diseases, fibrosis, and oncology. 

·Determine mechanism of action for drug targets; design and execute proof-of-concept studies to validate targets together with internal and/or external partners.

·Perform preclinical candidate screening and optimization via combined in vitro and in vivo assays, working with or supported by cross-disciplinary groups, including chemistry, bioassay, histology, and in vivo pharmacology, and/or CROs.

·Lead liver-targeting projects from inception to IND filing; prepare key preclinical, clinical and regulatory documents, and patent application

·Proactively identify potential risks to programs; recommend mitigation plans and implement solutions using a diverse set of resources; contribute to research projects through creative ideas.

·Effectively manage multiple programs and deliver quality result with a high level of efficiency within sensitive timelines.

·Comply with appropriate SOPs and GxP guidelines; train associates to meet requirements; present research findings to project teams, governance bodies, or external meetings. 

·Effectively communicate across all organizational levels

 Qualification

·PhD in biology, pharmacology, or related discipline with 4+ years of experience in pharmaceutical/biotech industry or academic settings. The level of position will be determined by previous experience and achievements. 

·Experience in ASO/siRNA and/or gene/base editing is desired.

·Track record of independent research and creativity, as demonstrated by quality publications and/or patents

·Understanding physiology and mechanisms behind liver-targeting diseases

·Knowledge and ability to develop biochemical and molecular biology assays for RNA and protein quantification 

·Ability to work independently or collaboratively 

·Outstanding organizational and time management skills and must be a self-starter with the ability to thrive in a multi-disciplinary, collaborative, fast-paced, and team-oriented environment.

·Excellent verbal and written communication skills